Treatment should only be continued if beneficial effects are seen. Dissociative Chemical Diffefence Image Chart: Confused 2. For those who want to use memantine for … M.A. Memantine hydrochloride, USP occurs as a fine white to off-white powder and is soluble in water. Results: Pretreatment with memantine attenuated the craving for alcohol before alcohol administration, but not after alcohol was given. My sense of balance and coordination were fairly thrown off. A subreddit for the sharing and discussion of research chemical vendors. Memantine (0, 15, and 30 mg) was administered 4 h before alcohol (1.5 g/l body water), which was given in four divided doses every 20 min. Memantine hydrochloride 20 mg film-coated tablets are I then took 50mg in the morning followed by 50mg more in the afternoon. As it stands the dosing range on Memantine's Psychonaut Wiki page was submitted by a single user with unknown sources. Keiski, in New Therapeutics for Traumatic Brain Injury, 2017. Welcome to r/DXM - the official subreddit for discussion of the powerful dissociative cough suppressant - Dextromethorphan! Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. This has taken me several hours before and by the time I've reached the depths of the memanverse I've forgotten I was even in my bed before (or wherever), leaving me in great voids and dark, space-filled structures, with no thoughts about the outside world. Also known as: Namenda, Namenda XR. For me, nothing works. I'm also a woman of normal height and weight (5'6"; 125 lbs). Your doctor will need to check your progress while you are using memantine. Constipation 3. I've also tabulated this data for easier reading: I was gonna post my report haha thank you for beating me to it. It was when I found a source or Memantine powder that I started experimenting with more recreational doses. I consider trying to get high off memantine to be about as good an idea as trying to trip off benadryl or nutmeg. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. When you first start taking this medication, you will usually take it once daily. Memantine hydrochloride oral solution belongs to a class of medicines called NMDA (N-methyl-D-aspartate) inhibitors. Do some research, ask a question, get an answer. I've taken as high as 200mg (with tolerance). For more information on Memantine read: Memantine Wikipedia Find more subreddits like r/MemantineHCl -- A sub for discussing all uses of Memantine, from therapeutic to recreational. A subreddit dedicated to people who have there own drug gardens. The things that do work/produce an effect will eventually have a deleterious effect on the mind. Make sure you follow the RULES. We are a community of dissociative enthusiasts and harm reductioners here to discuss the effects, safety, and a list of other things that all have to deal with dissociatives! Every bit helps, even if you didn't enjoy Memantine, it's important for people to know what they can before deciding to try the drug themselves. You may need to read it again. The next day, I often feel achey and sore all over. This is a subreddit about DPH. All I can say is its a very clean dissociative. Confidence issues are because I feel that I haven't accomplished anything in my life besides a highschool diploma. This includes prescription medications, street drugs and anything else with recreational potential that is uncommon or hard to find. You can read more specifically which term describes what range of effects here. Memantine, or known as Memantine HcL, is an uncompetitive NMDA receptor antagonist, and thus relies on glutamate’s activation of the NMDA receptor to take effect. Contraindications. There's no element of confusion at all. And personally, I've never had a bad time while under the influence. Memantine is a useful nootropic in the 10mg-60mg range daily, ONCE YOU GET USED TO IT, which can take a couple months, and slows opiate and stimulant tolerance buildup a bit. It has a role as a dopaminergic agent, an antiparkinson drug, a NMDA receptor antagonist, a neuroprotective agent and an antidepressant. I was pretty dissociated but it lacked the euphoria and pretty much any 'fun' aspect of a recreational dissociative. The self awareness memantine provides is one of the key factors why I enjoy it over other dissos, you can very easily gauge how much it is effecting you and take precautions so your situation is rarely ever precarious. It's difficult to tell if you've reached the Mem-Hole or not, because in my experience, to really achieve it you have to find a very calm place, allow your mind to drift and more or less meditate for a lack of a better term, until you've disconnected from reality. A friend of mine liked it so I just gave it to him. memantine Hydrochloride Tablet is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. This drug will pretty much wreck your dissociative tolerance, so don't plan on getting much fun out of any other dissos for weeks or maybe months after a recreational dose of memantine. Check out the /del/ discord: https://discord.gg/G3yV8Te, Tianeptine (Stablon) Discussion & Experiences. I didn't feel much with the first dose, possibly due to an increased tolerance since it wasn't super long since the last time I took it, (which I do not recommend... apparently taking it to often can fux with neuroplasticity levels), but a few hours after the second dose things got pretty warbly. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I bought memantine awhile back and took 15mg twice a day for 3 days. NAMENDA oral solution contains memantine hydrochloride in a strength equivalent to 2 mg of memantine hydrochloride in each mL. Warnings and Precautions For the discussion of recreational pharmacology. 1st time, 100mg : This drug takes a while to come up on that's for sure. Definitely a much clearer headed high than other dissociatives, lacking most of the traditional body high in exchange for a more cerebral oddity type feel. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, … YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. Also consider supporting Psychonaut Wiki & Erowid as they provide invaluable information for free to anyone who needs it. I am done with my experimentation. Theres also a memantine powder vendor on reddit, with great prices. Just wanted to put some stuff out there as there's not a whole helluva lot of reading material on memantine. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. View Entire Discussion (30 Comments) More posts from the Nootropics community. So I first started using Memantine to help reduce tolerance for dextraomphetamine which I take daily for ADHD. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. And it lasts fucking forever, so you take 100mg and you don't like it, prepare to feel that way for three days and likely have a car accident and some serious amnesia. 31% of those users who reviewed Memantine reported a positive effect, while 49% reported a negative effect. For people who enjoy both gardening and drugs. Take this medication by mouth with or without food as directed by your doctor. That's how it is for me at least. Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. Dawkę, okres oraz częstotliwość stosowania ustala lekarz. I got a little bit of double vision as this dose, with a slight amount of other dissociatives visuals, mainly scenery slicing. Memantine is great. Dizzy 6. I think it's interesting that you, and like others have reported, have said that you're fully aware of the impairment memantine brings, although it's not a turn off for you. * Chemistry-related DPH stuff I was able to mix 50 mg of memantine hydrochloride into 1 ml of distilled water only after applying light heat to increase solubility. https://erowid.org/experiences/exp.php?ID=109838, https://erowid.org/experiences/exp.php?ID=109789, https://erowid.org/experiences/exp.php?ID=105696, https://erowid.org/experiences/exp.php?ID=100894, https://drugs-forum.com/threads/100mg-memantine.248883/, https://erowid.org/experiences/exp.php?ID=32398, https://drugs-forum.com/threads/memantine-experience.286366/, https://drugs-forum.com/threads/memantine-experience-high-dose.296411/. memantine Hydrochloride 10 mg tablet: round, film-coated tablets are gray, with the strength (M10) debossed on one side and X on the other. Ask questions about drugs that you already typed into google, After the slow and painful death of MXE in 2015, researchers of the research chemical community have been searching for a replacement. So I've tried memantine at recreational doses about 3 different times now, this is what I have to report. Keep this leaflet. I am interested in getting it again though and using it for tolerance to stimulants because long story short, I have crippling anxiety, have used benzos for it, they make it way worse and have caused a lot of problems for me, I've basically came to the conclusion that I'm anxious because of confidence issues. Get your prescription refilled before you run out of medicine completely. But at the same time, I"m 100% consciously aware of the fact that my cognitive abilities are impaired. A threshold dose is the minimum dose required to feel the recreational effects, with each range increasing in effects. Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane.A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. Memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer's disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up to 28 weeks. Hey I can contribute! * Experiences you had with DPH One interesting memantine side effect includes higher libido. Well it got to be pretty late in the evening to I attempted to get to bed, but at 300mg there was no way I slept very much. Experiences, questions, no source / vendor discussion. I took 150mg the next day and had a Bon fire. Memantine. There are common reports of an uncomfortable slowing of thought processing, but for many it isn't enough to warrant dislike of the drug. Plants, cactus, mushrooms, herbs, and others are welcome. The 2nd time I honestly didn't notice much of an inebriation at all, all in all this seems to be a fairly "clear-headed" dissociative in my opinion. A friend and I went exploring as I just bought this house and it's pretty much in the middle of nowhere. Molecular Weight 215.76 . Posted by 2 days ago. It is taken by mouth. EC Number 255-219-6. Colors were much more defined, and everything became surreal almost as if it were placed there with some higher meaning, like the "doll-house" effect, maybe I should call it the "M-house" effect, lol. Tabletki należy połykać, popijając niewielką ilością wody. This is yet another reason why I love this substance, I don't think I've had such a clean and clear headed disconnection from reality without feeling heavily impaired at the same time. At the peak of the dissociation, I find it difficult to communicate with people (mainly via text). For all your inquiries/input/general information about using GABAergic Drugs (Phenibut, Gabapentin, Benzo's etc). A psychonaut is a person who experiences intentionally induced altered states of consciousness and claims to use the experience to investigate his or her mind, and possibly address spiritual questions, through direct experience. From experience the tolerance issues come heavily into play when dosing more regularly or for a longer period than this. Haven't felt any Euphoria yet within 2hrs of taking it initially at 10.00pm. Hunting ethnobotanicles is also encouraged. I have one question for you:If you've taken 300mg in about a 4 hour period, how much would you think you would need to reach the "Mem-Hole"? Memantine HCl occurs as a fine white to off-white powder and is soluble in water. These medications may interact and cause very harmful effects. As for your comment about car accidents, any reasonable user should be smart enough and aware of the dangers of driving on any substance, this sub and the other resources available are meant to reduce harm and educate users about the risks involved with Memantine use. Head Pain Diarrhea 5. Memantine hydrochloride has been marketed as Namenda by Forest Laboratories in the United States and as Ebixa by Lundbeck in Europe, although generic formulations of the tablets are now available. Very pleasant dreams. Memantine is a useful nootropic in the 10mg-60mg range daily, ONCE YOU GET USED TO IT, which can take a couple months, and slows opiate and stimulant tolerance buildup a bit. Memantine: Formulations, Dosages, Contraindications, and Side Effects. HCl . While being very dissociated, I'm able to think properly and rationally. But it wasn't very fun. Basically, for me, it took around 150mg to be 'recreational'. Memantine hydrochloride oral solution is a prescription medicine used for the treatment of moderate to severe dementia in people with Alzheimer's disease. Serious Interactions. This extends into what is the Memantine equivalent of a K-hole, which when compared to Ketamine is much more clear-headed. Both the research  and anecdotal reports  recount as much. Memantine hydrochloride extended-release capsules were evaluated in a double-blind placebo-controlled trial in which a total of 676 patients with moderate to severe dementia of the Alzheimer’s type (341 patients on memantine hydrochloride extended-release capsules 28 mg/day and 335 patients on placebo) for a treatment period up to 24 weeks. Modafinil (Provigil, Modalert) and related compounds. 348. Memantine has an average rating of 4.6 out of 10 from a total of 35 ratings for the treatment of Alzheimer's Disease. A sub dedicated to PCP, Ketamine, MXE, Diphenidine, DXM, MK-801 and more! Memantine is a prescription drug. Pictures and discussions. 6.1 Clinical Trials Experience. If you don't see your submission or have a problem feel free to message the moderators. I weigh 120lbs-125lbs. Ill continue later.... New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. Examples: morning glory, peyote, San Pedro, datura, Hawaiian baby woodrose, mimosa hostilis, etc. Use memantine regularly to get the most benefit. Discussion of nootropics and cognitive enhancers. You've made some really interesting points, firstly you're right about taking it too often, I've said in other threads but I strongly recommend against taking recreational doses more than once every 2 weeks and for no more than 3-4 fortnights in a row. Consequently, there is a large pool of high-quality evidence that supports memantine’s use in moderate-to-severe cases of Alzheimer’s disease (AD). Slightly dissociated, but no miracle like I was hoping for. If there's any questions I'll do my best to elucidate on the experience, hope this helps! The 3rd time I took 150mg, followed by another 150mg about 4 hours later. (Examples: Dexamyl, Placidyl, Diconal, Miltown). Keep the liquid medicine bottle tightly closed with the cap provided. Trying 50mg Memantine tonight. These are currently the few reliable reports of recreational Memantine use: Reported Dose: 150mgDescribed Experience: Heavy (Hole-like experience)Reported Tolerance: unknown, some dissociative experienceSource: https://erowid.org/experiences/exp.php?ID=109838, Reported Dose: 150mgDescribed Experience: Heavy (Hole-like experience)Reported Tolerance: Experienced userSource: https://erowid.org/experiences/exp.php?ID=109789, Reported Dose: 20mg (In conjunction with 600mg of Gabapentin)Described Experience: Threshold-LightReported Tolerance: Zero experience with Memantine, some experience with other dissociativesSource: https://erowid.org/experiences/exp.php?ID=105696, Reported Dose: 100mgDescribed Experience: Common-StrongReported Tolerance: some dissociative experienceSource: https://erowid.org/experiences/exp.php?ID=100894, Reported Dose: 100mgDescribed Experience: CommonReported Tolerance: unknown, user reports previous use of DXMSource: https://drugs-forum.com/threads/100mg-memantine.248883/, Reported Dose: 4x doses ranging between 50-100mg (200-400mg total)Described Experience: HeavyReported Tolerance: unknownNote: recommends 50-100mg for common useSource: https://erowid.org/experiences/exp.php?ID=32398, Reported Dose: 80-100mgDescribed Experience: Light-CommonReported Tolerance: unknownSource: https://drugs-forum.com/threads/memantine-experience.286366/, (From the same thread as above)Reported Dose:50mg (1st Day), 90mg (2nd Day), 160mg (3rd Day)Described Experience:Day 1: (Light), Day 2: (Light-Common), Day 3: (Strong)Reported Tolerance: UnknownSource: https://drugs-forum.com/threads/memantine-experience.286366/, Reported Dose: 280mgDescribed Experience: Strong-HeavyReported Tolerance: unknownSource:https://drugs-forum.com/threads/memantine-experience-high-dose.296411/. http://scs-assets-cdn.vice.com/int/v18n2/htdocs/interview-with-ketamine-chemist-704/drug-structures.gif. * Combinations you tried or want to try Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. (r/drugs with longer words). Please also state how often you are dosing and with what dosages, and please describe roughly what you believe your tolerance to be. This subreddit is mostly powered by research from [Examine.com](http://examine.com/), and some reading of the supplement on hand (either at this site or other sources) before posting is encouraged to facilitate discussion. A place to discuss Salvia divinorum, a psychoactive plant traditionally used by Mazatec shamans. In conjunction with the psychonaut wiki, we are seeking to create a more reliable and standardized recommended dosing range for recreational use of Memantine. Don't take phenibut before you understand the risks and side effects. If experienced, these tend to have a Less Severe expression 1. For full subreddit functionality, we recommend OPTING OUT of the redesign in your settings! ), and general discussions on different categories of supplementation.